Nephrology
Feasibility Assessment
Part C: Treatment Strategies for CKD-Associated Anemia
How would you characterize the following changes to your anemia management practice compared with 5 years ago?
Select one per category
Amount of clinical focus on anemia management
More today
Similar
Less today
Stage at which anemia workup is initiated
Earlier in CKD course today
Similar
Later in CKD course today
Your approach to iron optimization before erythropoiesis-stimulating agents (ESA)
More aggressive with iron optimization today (eg, earlier initiation and/or higher IV iron dosing)
Similar
Less aggressive with iron optimization today
Why has this changed over the past 5 years?
Frequency that iron optimization alone can resolve anemia
More frequently today
Similar
Less frequently today
Number of patients reaching later-stage CKD requiring an ESA
More today
Similar
Fewer today
Why has this changed over the past 5 years?
Transfusion frequency
More common today
Similar
Less common today
Why has the transfusion frequency increased over the past 5 years?
Kidney transplants
More frequent today
Similar
Less frequent today
At what hemoglobin level do you typically initiate an anemia workup in your patients with kidney disease?
For ESKD patients:
Enter number
g/L
How does this threshold compare with 5 years ago?
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
For CKD patients:
Enter number
g/L
How does this threshold compare with 5 years ago?
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
Over the past 5 years, how has your iron management approach changed?
Select all that apply
More proactive iron optimization before ESA initiation
Increased use of iron to delay or avoid ESA initiation
Mode of iron administration (IV vs oral)
Iron formulation used
Increased use of IV iron in pre-dialysis CKD patients
More conservative use of IV iron
No meaningful change in iron management
Other
How have these changes in your iron management affected ESA use in your practice?
Select one
Delay in ESA initiation
Reduced ESA dose requirements
No meaningful impact
Increased ESA use
Unsure
In your practice, what newer therapy/therapies have impacted CKD progression or anemia management?
Enter therapy(s) and rate each impact
Rate how "@therapy@" has impacted the following variables:
Substantially Decreased
⇔
Substantially Increased
Rate of CKD progression
Prevalence of anemia
Frequency of IV iron use
Frequency of ESA initiation
Average dose of ESA
Rate how "@therapy@" has impacted the following variables:
Substantially Decreased
⇔
Substantially Increased
Rate of CKD progression
Prevalence of anemia
Frequency of IV iron use
Frequency of ESA initiation
Average dose of ESA
Approximately what proportion of your dialysis patients currently receives ESA therapy?
Enter numbers
Institutional dialysis
Home modalities
Current proportion:
%
%
Proportion from 5 years ago:
%
%
Approximately what proportion of your CKD patients currently receives ESA therapy?
Enter numbers
Current:
%
5 years ago:
%
What hemoglobin level do you typically use to initiate ESA therapy in dialysis patients with adequate iron repletion?
For Hemodialysis (HD):
Enter numbers
g/L
How does this threshold compare with 5 years ago?
Select one
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
For Home modalities:
Enter numbers
g/L
How does this threshold compare with 5 years ago?
Select one
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
What hemoglobin maintenance level do you typically target in ESKD patients receiving ESA therapy?
Enter number
g/L
How does this threshold compare with 5 years ago?
Select one
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
What hemoglobin level do you typically use to initiate ESA therapy in CKD patients with adequate iron repletion?
Enter number
g/L
How does this threshold compare with 5 years ago?
Select one
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
What hemoglobin maintenance level do you typically target in CKD patients receiving ESA therapy?
Enter number
g/L
How does this threshold compare with 5 years ago?
Select one
Higher threshold today (more aggressive)
Similar
Lower threshold today (more conservative)
What is your preferred first-line ESA agent for ESKD patients?
Select one
ARANESP (darbepoetin alfa)
Epoetin alfa
No strong preference
Rarely initiate ESA
What is your preferred first-line ESA agent for CKD patients?
Select one
ARANESP (darbepoetin alfa)
Epoetin alfa
No strong preference
Rarely initiate ESA
Do you currently use hemodiafiltration (HDF)?
Select one
Yes
No
Approximately what proportion of your dialysis patients receive HDF vs conventional hemodialysis?
Enter percentage for each
HDF:
%
Conventional hemodialysis:
%
Compared with conventional hemodialysis, have you observed any difference in hemoglobin levels or ESA requirements in patients receiving HDF?
Select one
Yes, HDF patients tend to maintain higher hemoglobin with less ESA
Yes, some difference, but the clinical impact is modest
No meaningful difference noticed in hemoglobin or ESA requirements
To what extent are each of the following COVID-19–related factors still influencing your clinical practice today?
Select one for each
No longer a factor
<=>
Significant ongoing impact
Disruption to CKD referral pipeline
Backlog of more advanced or complex referrals
Nursing staff shortage
Physician staff shortage
Shift to telehealth visits